caa a22 4500 475844998 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000666 doi (NATIONALLICENCE)springer-10.1007/PL00000666 Whanger P. D. Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis (Oregon 97331, USA), Fax +1 541 737 0497, e-mail: phil.whanger@orst.edu, US aut Selenoprotein W: a review [Elektronische Daten] [P. D. Whanger] Abstract.: Purification of selenoprotein W (Se-W) from rat and monkey muscles was shown to exist in multiple forms: with or without reduced glutathione and/or a 41-Da moiety (identity still unknown). TGA is located at coding position 13 in Se-W complementary DNA (cDNA) from all five species studied (rats, mice, sheep, human and monkey). TGA is also the stop codon in the rodents and sheep cDNA, but TAA is the stop codon in primates. There is an 80% homology of the nucleotide sequence in the coding region among the five species of animals, and the predicted amino acid sequences are 83% identical (rodents identical and primates identical). Se-W levels are highest in muscle, heart and brain from sheep and primates, but very low in rodent hearts. Studies with tissue cultures of muscle and brain cells indicated that selenium influenced Se-W levels. Although the metabolic function of Se-W is unknown, preliminary data suggest that it has an antioxidant function. Birkhäuser Verlag Basel,, 2000 Key words. Selenoprotein W nationallicence tissue distribution nationallicence rodents nationallicence primates nationallicence sheep nationallicence amino acid and nucleotide sequences nationallicence https://doi.org/10.1007/PL00000666 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000666 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Whanger P. D. Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis (Oregon 97331, USA), Fax +1 541 737 0497, e-mail: phil.whanger@orst.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer