caa a22 4500 475845021 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000670 doi (NATIONALLICENCE)springer-10.1007/PL00000670 Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum [Elektronische Daten] [E. Raux, H. L. Schubert, M. J. Warren*] Abstract.: The biosynthesis of cobalamin (vitamin B12) is described, revealing how the concerted action of around 30 enzyme-mediated steps results in the synthesis of one of Nature's most structurally complex ‘small molecules'. The plethora of genome sequences has meant that bacteria capable of cobalamin synthesis can be easily identified and their biosynthetic genes compared. Whereas only a few years ago cobalamin synthesis was thought to occur by one of two routes, there are apparently a number of variations on these two pathways, where the major differences seem to be concerned with the process of ring contraction. A comparison of what is currently known about these pathways is presented. Finally, the process of cobalt chelation is discussed and the structure/function of the cobalt chelatase associated with the oxygen-independent pathway (CbiK) is described. Birkhäuser Verlag Basel,, 2000 Key words. Cobalamin nationallicence vitamin B12 nationallicence tetrapyrrole nationallicence precorrin nationallicence chelatase nationallicence pathway nationallicence Raux E. School of Biological Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS(UK), Fax +4420 8983 0973, e-mail: m.j.warren@qmw.ac.uk, GB aut Schubert H. L. Department of Biochemistry, University of Utah, Salt Lake City (Utah 84132, USA) aut Warren* M. J. School of Biological Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS(UK), Fax +4420 8983 0973, e-mail: m.j.warren@qmw.ac.uk, GB aut https://doi.org/10.1007/PL00000670 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000670 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raux E. School of Biological Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS(UK), Fax +4420 8983 0973, e-mail: m.j.warren@qmw.ac.uk, GB aut NATIONALLICENCE 700 1- Schubert H. L. Department of Biochemistry, University of Utah, Salt Lake City (Utah 84132, USA) aut NATIONALLICENCE 700 1- Warren* M. J. School of Biological Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS(UK), Fax +4420 8983 0973, e-mail: m.j.warren@qmw.ac.uk, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer