caa a22 4500 475845072 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000663 doi (NATIONALLICENCE)springer-10.1007/PL00000663 Stapleton S. R. Department of Chemistry, Western Michigan University, Kalamazoo (Michigan 49008, USA), Fax +1 616 387 2909, e-mail: stapleton@wmich.edu, US aut Introduction: The selenium conundrum [Elektronische Daten] [S. R. Stapleton] Abstract.: Selenium was first suspected of being an essential dietary trace element in the 1950s. We now know that indeed it is an essential biological element that serves as an integral component of several enzymes, including those in the families of deiodinases and glutathione peroxidases as well as selenoproteins P and W. The multi-author review that follows this introduction concentrates on the important biological role of selenium in enzymes as well as some of the physiological aspects of selenium as either a potential anticarcinogenic agent or insulin mimetic. What should become clear from these contributed articles is the complex and dynamic role that selenium plays in many biological processes and that the investigations in these areas are at the edge of exciting new frontiers. Birkhäuser Verlag Basel,, 2000 Key words. Selenium nationallicence deiodinases nationallicence glutathione peroxidases nationallicence selenoprotein P nationallicence selenoprotein W nationallicence anticarcinogenic agent nationallicence insulin mimetic nationallicence https://doi.org/10.1007/PL00000663 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000663 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Stapleton S. R. Department of Chemistry, Western Michigan University, Kalamazoo (Michigan 49008, USA), Fax +1 616 387 2909, e-mail: stapleton@wmich.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer