caa a22 4500 475845080 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000667 doi (NATIONALLICENCE)springer-10.1007/PL00000667 Köhrle J. Abteilung Molekulare Innere Medizin der Medizinischen Poliklinik der Universität Würzburg, Roentgenring 11, D-97070 Wuerzburg (Germany), Fax +0049 931 201 7107, e-mail:j.koehrle@mail.uni-wuerzburg.de, DE aut The deiodinase family: selenoenzymes regulating thyroid hormone availability and action [Elektronische Daten] [J. Köhrle] Abstract.: Thyroid hormones control growth, development, differentiation and metabolism in vertebrates. Most of the actions of the active thyroid hormone T3 (3,5,3′-triiodo-l-thyronine) are exerted via ligand-activated nuclear T3 receptors. Activation of the secretory product of the thyroid gland, l-thyroxine (3,3′,5,5′-tetraiodo-l-thyronine), or T4, is catalyzed by two enzymes, iodothyronine-5′-deiodinases type I and type II. Inactivation of T4 and T3 occurs via type III iodothyronine-5-deiodinase and to some extent by type I 5′-deiodinase. Complementary DNAs (cDNAs) encoding the substrate-binding selenocysteine-containing subunits of the deiodinases were cloned, though some controversy still exists on the type II 5′-deiodinase subunits. Characterization of tissue-specific expression patterns indicates that these selenium-dependent enzymes exert tight control on local and systemic availability of active T3. Thus, deiodinases are envisaged as guardians to the gate of thyroid hormone action mediated by T3 receptors. Birkhäuser Verlag Basel,, 2000 Key words. Thyroid hormone metabolism nationallicence selenoenzymes nationallicence deiodination nationallicence thyroxine nationallicence triiodothyronine nationallicence development nationallicence comparative endocrinology nationallicence receptor nationallicence https://doi.org/10.1007/PL00000667 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000667 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Köhrle J. Abteilung Molekulare Innere Medizin der Medizinischen Poliklinik der Universität Würzburg, Roentgenring 11, D-97070 Wuerzburg (Germany), Fax +0049 931 201 7107, e-mail:j.koehrle@mail.uni-wuerzburg.de, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer