caa a22 4500 475845099 CHVBK 20180406123911.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000674 doi (NATIONALLICENCE)springer-10.1007/PL00000674 Regulation of the type III InsP3 receptor and its role in β cell function [Elektronische Daten] [R. E. Hagar*, B. E. Ehrlich] Abstract.: The type III inositol 1,4,5-trisphosphate receptor (InsP3R) is an important intracellular calcium (Ca2+) release channel in the pancreatic β cell. Pancreatic β cells secrete insulin following a characteristic change in membrane potential that leads to an increase in cytoplasmic Ca2+. Both extracellular Ca2+ and Ca2+ mobilized from InsP3-sensitive stores contribute to this increase. RIN-m5F cells, an insulin-secreting β cell line, preferentially express the type III InsP3R . These cells have been useful in determining the regulatory properties of the type III InsP3R and the role of this isoform in an intact cell. The type III InsP3R is ideal for signal initiation because high cytoplasmic Ca2+ does not inhibit its activity . Altered insulin secretion, the result of changes in Ca2+ handling by the β cell, has significant clinical consequences. Birkhäuser Verlag Basel,, 2000 Key words. Ion channel gating nationallicence calcium channels nationallicence inositol 1,4,5-trisphosphate nationallicence kinetics nationallicence lipid bilayers nationallicence Hagar* R. E. Department of Physiology, University of Connecticut Health Center, Farmington (Connecticut 06030 USA) aut Ehrlich B. E. Department of Pharmacology, Yale University, 333 Cedar Street, New Haven (Connecticut 06520, USA), Fax +1 203 785 7670 aut https://doi.org/10.1007/PL00000674 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000674 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hagar* R. E. Department of Physiology, University of Connecticut Health Center, Farmington (Connecticut 06030 USA) aut NATIONALLICENCE 700 1- Ehrlich B. E. Department of Pharmacology, Yale University, 333 Cedar Street, New Haven (Connecticut 06520, USA), Fax +1 203 785 7670 aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer