caa a22 4500 475845102 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000678 doi (NATIONALLICENCE)springer-10.1007/PL00000678 Lysophosphatidic acid: receptors, signaling and survival [Elektronische Daten] [J. T. Swarthout*, H. W. Walling] Abstract.: Though the mitogenic activity of lysophosphatidic acid (LPA) has been wellestablished through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions. In addition to its mitogenic properties, recent reports have suggested that LPA may also promote cell survival. This review will summarize the current literature regarding LPA signaling and its role as an antiapoptotic factor. Birkhäuser Verlag Basel,, 2000 Key words. G-protein-coupled receptors nationallicence apoptosis nationallicence mitogen nationallicence calcium mobilization nationallicence smooth muscle contraction nationallicence phosphatidylinositol nationallicence Swarthout* J. T. Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis (Missouri 63104, USA), Fax 314 577 8233, e-mail: swarthjt@slu.edu, US aut Walling H. W. Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis (Missouri 63104, USA), Fax 314 577 8233, e-mail: swarthjt@slu.edu, US aut https://doi.org/10.1007/PL00000678 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000678 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swarthout* J. T. Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis (Missouri 63104, USA), Fax 314 577 8233, e-mail: swarthjt@slu.edu, US aut NATIONALLICENCE 700 1- Walling H. W. Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis (Missouri 63104, USA), Fax 314 577 8233, e-mail: swarthjt@slu.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer