caa a22 4500 475845110 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000669 doi (NATIONALLICENCE)springer-10.1007/PL00000669 Stapleton S. R. Department of Chemistry, Western Michigan University, Kalamazoo (Michigan 49008, USA), Fax +1 616 387 2909, e-mail: stapleton@wmich.edu, US aut Selenium: an insulin mimetic [Elektronische Daten] [S. R. Stapleton] Abstract.: Insulin or agents that can mimic its action (insulin mimetics) are necessary to promote the entry of glucose into tissues where the glucose can either be converted into energy or stored for later use. In recent years, selenium has been shown to mediate a number of insulin-like actions both in vivo and in vitro. These insulin-like actions include stimulating glucose uptake and regulating metabolic processes such as glycolysis, gluconeogenesis, fatty acid synthesis and the pentose phosphate pathway. The mechanism by which selenium is capable of mimicking insulin is not clear; however, reports indicate that selenium does activate key proteins involved in the insulin-signal cascade. Various proteins in the insulin-signal cascade have been shown to be necessary for different insulin-regulated events, and presumably data will be forthcoming soon that illustrate this similarly for selenium. This review compares the action of selenium to that of insulin and discusses the available evidence in support of selenium as an insulin mimetic. Birkhäuser Verlag Basel,, 2000 Key words. Selenium nationallicence insulin-mimetic nationallicence glucose metabolism nationallicence diabetes nationallicence https://doi.org/10.1007/PL00000669 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000669 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Stapleton S. R. Department of Chemistry, Western Michigan University, Kalamazoo (Michigan 49008, USA), Fax +1 616 387 2909, e-mail: stapleton@wmich.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer