caa a22 4500 475845145 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/PL00000665 doi (NATIONALLICENCE)springer-10.1007/PL00000665 Persson Moschos M. Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden), Fax +46 46 23853, e-mail: marie.persson@kc.lu.se, SE aut Selenoprotein P [Elektronische Daten] [M. Persson Moschos] Abstract.: Selenoprotein P (SeP) is an extracellular, monomeric glycoprotein containing up to 10 selenocysteine residues in the polypeptide chain. It is ubiquitously expressed in mammalian tissues, and in human plasma it accounts for at least 40% of the total selenium concentration. SeP binds to heparin and cell membranes, and is associated with endothelial cells. SeP in human plasma protects against peroxynitrite-mediated oxidation and reduces phospholipid hydroperoxide in vitro, in accordance with the presumption that it has a function as an extracellular oxidant defense. Immunochemical assays have demonstrated that its concentration in plasma varies much with selenium intake, but other factors also have an influence. Birkhäuser Verlag Basel,, 2000 Key words. Selenoprotein P nationallicence plasma nationallicence selenocysteine nationallicence heparin-binding protein nationallicence endothelial cells nationallicence oxidant defense nationallicence selenium status nationallicence https://doi.org/10.1007/PL00000665 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000665 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Persson Moschos M. Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden), Fax +46 46 23853, e-mail: marie.persson@kc.lu.se, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer