caa a22 4500 475845196 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/PL00000730 doi (NATIONALLICENCE)springer-10.1007/PL00000730 Scarborough G. A. Department of Pharmacology, School of Medicine, Campus Box #7365 Jones Building, University of North Carolina at Chapel Hill, Chapel Hill (North Carolina 27599, USA), Fax +1 919 966 5640, e-mail: gas@med.unc.edu, US aut The plasma membrane proton-translocating ATPase [Elektronische Daten] [G. A. Scarborough] Abstract.: Living cells require membranes and membrane transporters for the maintenance of life. After decades of biochemical scrutiny, the structures and molecular mechanisms by which membrane transporters catalyze transmembrane solute movements are beginning to be understood. The plasma membrane proton-translocating adenosine triphosphatase (ATPase) is an archetype of the P-type ATPase family of membrane transporters, which are important in a wide variety of cellular processes. The H+-ATPase has been crystallized and its structure determined to a resolution of 8 Å in the membrane plane. When considered together with the large body of biochemical information that has been accumulated for this transporter, and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by this enzyme. Birkhäuser Verlag Basel,, 2000 Key words. Membrane transport nationallicence membrane protein crystallization nationallicence P-type ATPases nationallicence proton pump nationallicence membrane protein structure nationallicence conformational changes nationallicence molecular dynamics nationallicence https://doi.org/10.1007/PL00000730 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000730 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Scarborough G. A. Department of Pharmacology, School of Medicine, Campus Box #7365 Jones Building, University of North Carolina at Chapel Hill, Chapel Hill (North Carolina 27599, USA), Fax +1 919 966 5640, e-mail: gas@med.unc.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer