caa a22 4500 475845218 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/PL00000736 doi (NATIONALLICENCE)springer-10.1007/PL00000736 Regulation of BMP/Dpp signaling during embryonic development [Elektronische Daten] [T. Nakayama*, Y. Cui*, J. L. Christian**] Abstract.: Bone morphogenetic protein-4 (BMP-4) and its Drosophila ortholog, decapentaplegic (Dpp), are multifunctional developmental regulators. Both gain-of-function and loss-of-function studies demonstrate that the biological activity and signaling range of these morphogens must be strictly regulated to ensure normal embryonic patterning. BMP-4 and Dpp are produced from inactive precursors that are proteolytically cleaved, following which the active ligand is secreted into the extracellular space. Binding of BMP-4 or Dpp to its cognate receptor leads to phosphorylation of intracellular signal-transducing Smad proteins that then form hetero-oligomers, translocate to the nucleus and modulate transcription of target genes. Recent studies have shown that the BMP signal transduction cascade can be modulated at every step of this process. Birkhäuser Verlag Basel,, 2000 Key words. Bone morphogenetic protein (BMP) nationallicence Smad, decapentaplegic (Dpp) nationallicence embryo nationallicence signal transduction nationallicence Nakayama* T. Department of Cell and Developmental Biology, L215, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland (Oregon 97201-3098, USA), Fax +1 503 494 4253, e-mail: christia@ohsu.edu, US aut Cui* Y. Department of Cell and Developmental Biology, L215, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland (Oregon 97201-3098, USA), Fax +1 503 494 4253, e-mail: christia@ohsu.edu, US aut Christian** J. L. Department of Cell and Developmental Biology, L215, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland (Oregon 97201-3098, USA), Fax +1 503 494 4253, e-mail: christia@ohsu.edu, US aut https://doi.org/10.1007/PL00000736 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000736 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakayama* T. Department of Cell and Developmental Biology, L215, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland (Oregon 97201-3098, USA), Fax +1 503 494 4253, e-mail: christia@ohsu.edu, US aut NATIONALLICENCE 700 1- Cui* Y. Department of Cell and Developmental Biology, L215, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland (Oregon 97201-3098, USA), Fax +1 503 494 4253, e-mail: christia@ohsu.edu, US aut NATIONALLICENCE 700 1- Christian** J. L. Department of Cell and Developmental Biology, L215, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland (Oregon 97201-3098, USA), Fax +1 503 494 4253, e-mail: christia@ohsu.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer