caa a22 4500 475845234 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/PL00000735 doi (NATIONALLICENCE)springer-10.1007/PL00000735 New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia [Elektronische Daten] [H. Werner, D. Le Roith*] Abstract.: The insulin-like growth factors (IGFs) are a ubiquitous family of growth factors, binding proteins and receptors that are involved in normal growth and development. They are also implicated in numerous pathological states, including malignancy. IGF-II is a commonly expressed growth factor in many tumors and may enhance tumor growth, acting via the overexpressed IGF-I receptor, a cell-surface tyrosine kinase receptor. The IGF-I receptor may be overexpressed due to mutations in tumor suppression gene products such as p53 and WT-1 or growth factors such as bFGF and PDGF. Thus, this family of growth factors, especially the IGF-I receptor, may present an excellent target for new therapeutic agents in the treatment of cancer and other disorders of excessive cellular proliferation. Birkhäuser Verlag Basel,, 2000 Key words. Insulin-like growth factors nationallicence IGF-I receptor nationallicence cancer nationallicence receptor signaling nationallicence Werner H. Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978 (Israel), IL aut Le Roith* D. Clinical Endocrinology Branch, Room 8D12, Bldg 10, NIH MSC 1758, Bethesda (Maryland 20892-1758, USA), Fax +1 301 480 4386, e-mail: derek@helix.nih.gov, US aut https://doi.org/10.1007/PL00000735 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000735 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Werner H. Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978 (Israel), IL aut NATIONALLICENCE 700 1- Le Roith* D. Clinical Endocrinology Branch, Room 8D12, Bldg 10, NIH MSC 1758, Bethesda (Maryland 20892-1758, USA), Fax +1 301 480 4386, e-mail: derek@helix.nih.gov, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer