caa a22 4500 475845269 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/PL00000732 doi (NATIONALLICENCE)springer-10.1007/PL00000732 Life without myoglobin [Elektronische Daten] [D. J. Garry*, A. Meeson, Z. Yan, R. S. Williams] Abstract.: Hemoproteins are widely distributed among prokaryotes, unicellular eukaryotes, plants and animals . Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria . This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists . Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin . This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle. Birkhäuser Verlag Basel,, 2000 Key words. Myoglobin nationallicence oxygen transport nationallicence heart nationallicence skeletal muscle nationallicence transgenic mice nationallicence Garry* D. J. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut Meeson A. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut Yan Z. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut Williams R. S. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut https://doi.org/10.1007/PL00000732 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000732 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garry* D. J. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut NATIONALLICENCE 700 1- Meeson A. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut NATIONALLICENCE 700 1- Yan Z. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut NATIONALLICENCE 700 1- Williams R. S. Department of Internal Medicine, 5323 Harry Hines Blvd., NB11.200, University of Texas Southwestern Medical Center, Dallas( Texas 75390-8573, USA), Fax +1 214 648 1450, e-mail: garry@ryburn.swmed.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer