caa a22 4500 475845366 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/PL00000742 doi (NATIONALLICENCE)springer-10.1007/PL00000742 Intracellular osmotic action [Elektronische Daten] [R. P. Rand*, V. A. Parsegian, D. C. Rau] Abstract.: Water often acts as a critical reactant in cellular reactions. Its role can be detected by modulating water activity with osmotic agents. We describe the principles behind this ‘osmotic stress' strategy, and survey the ubiquity of water effects on molecular structures that have aqueous, solute-excluding regions. These effects are seen with single-functioning molecules such as membrane channels and solution enzymes, as well as in the molecular assembly of actin, the organization of DNA and the specificity of protein/DNA interactions Birkhäuser Verlag Basel,, 2000 Key words. Water nationallicence osmotic stress nationallicence channels nationallicence enzymes nationallicence DNA nationallicence actin nationallicence Rand* R. P. Department of Biological Sciences, Brock University, St. Catharines, ON, L2S 3A1 (Canada), e-mail: rrand@spartan.ac.brocku.ca, CA aut Parsegian V. A. Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda (Maryland 20892-5626, USA), e-mail: aparsegi@helix.nih.gov,donrau@helix.nih.gov, US aut Rau D. C. Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda (Maryland 20892-5626, USA), e-mail: aparsegi@helix.nih.gov,donrau@helix.nih.gov, US aut https://doi.org/10.1007/PL00000742 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000742 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rand* R. P. Department of Biological Sciences, Brock University, St. Catharines, ON, L2S 3A1 (Canada), e-mail: rrand@spartan.ac.brocku.ca, CA aut NATIONALLICENCE 700 1- Parsegian V. A. Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda (Maryland 20892-5626, USA), e-mail: aparsegi@helix.nih.gov,donrau@helix.nih.gov, US aut NATIONALLICENCE 700 1- Rau D. C. Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda (Maryland 20892-5626, USA), e-mail: aparsegi@helix.nih.gov,donrau@helix.nih.gov, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer