caa a22 4500 475845420 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00000652 doi (NATIONALLICENCE)springer-10.1007/PL00000652 The role of Sonic hedgehog in neural tube patterning [Elektronische Daten] [I. Patten, M. Placzek*] Abstract.: In the developing neural tube of vertebrate embryos, many types of neural and nonneuronal cells differentiate in response to the secreted signalling molecule, Shh. Shh shows a spatially restricted pattern of expression in cells located at the ventral midline, yet governs the differentiation of diverse cell types throughout the ventral half of the neural tube. Here, we describe how the distinct fate assumed by cells in response to Shh is dependent upon their position with respect to both the dorso-ventral and anterior-posterior axes of the neural tube and describe the ways in which a single factor, Shh, is able to pattern the developing nervous system. We first discuss the evidence that Shh does impose ventral identity on cells in the neural tube, then focus on the role of a graded Shh signal in patterning the neural tube and finally discuss the interaction of Shh with other factors that affect its signalling outcome. Birkhäuser Verlag Basel,, 2000 Key words. Neural tube nationallicence development nationallicence neural cell differentiation nationallicence Patten I. MRC Intercellular Signalling Group, Developmental Genetics Programme, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom), e-mail: m.placzek@sheffield.ac.uk, GB aut Placzek* M. MRC Intercellular Signalling Group, Developmental Genetics Programme, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom), e-mail: m.placzek@sheffield.ac.uk, GB aut https://doi.org/10.1007/PL00000652 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000652 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patten I. MRC Intercellular Signalling Group, Developmental Genetics Programme, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom), e-mail: m.placzek@sheffield.ac.uk, GB aut NATIONALLICENCE 700 1- Placzek* M. MRC Intercellular Signalling Group, Developmental Genetics Programme, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom), e-mail: m.placzek@sheffield.ac.uk, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer