caa a22 4500 475845439 CHVBK 20180406123912.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00000661 doi (NATIONALLICENCE)springer-10.1007/PL00000661 Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer's disease and Down syndrome [Elektronische Daten] [S. H. Kim, R. Vlkolinsky, N. Cairns, G. Lubec*] Abstract.: Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer's disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD. Birkhäuser Verlag Basel,, 2000 Key words. Ubiquinol:cytochrome c oxidoreductase nationallicence ATP synthase nationallicence mitochondrial electron transport chain nationallicence Alzheimer's disease nationallicence Down syndrome nationallicence neuronal cell death nationallicence neurodegenerative disease nationallicence Kim S. H. Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at, AT aut Vlkolinsky R. Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at, AT aut Cairns N. Institute of Psychiatry, Brain Bank, King's College, London (U.K.), UK aut Lubec* G. Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at, AT aut https://doi.org/10.1007/PL00000661 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000661 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim S. H. Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at, AT aut NATIONALLICENCE 700 1- Vlkolinsky R. Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at, AT aut NATIONALLICENCE 700 1- Cairns N. Institute of Psychiatry, Brain Bank, King's College, London (U.K.), UK aut NATIONALLICENCE 700 1- Lubec* G. Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at, AT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer