caa a22 4500 475845501 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00000656 doi (NATIONALLICENCE)springer-10.1007/PL00000656 Structural studies on nuclear receptors [Elektronische Daten] [J. P. Renaud, D. Moras*] Abstract.: Nuclear receptors are DNA-binding factors which regulate the transcription of sets of specific genes in response to cognate ligands, usually small lipophilic molecules, thus controlling numerous physiological events in development, procreation, homeostasis, and cellular life. Their ligand-dependent activity makes nuclear receptors obvious targets for drug design in many therapeutic areas. Crystallographic studies have revealed the structure of isolated domains but not, yet, of a whole protein, probably due to an intrinsic flexibility at work in nuclear receptor action. The structure of DNA-binding domain dimers in complex with an oligonucleotide has brought insights into how nuclear receptors recognize and bind to their target sequences (‘response elements'). The structure of several ligand-binding domains in different ligation states has provided evidence for a ligand-dependent transcriptional switch and a molecular basis for the mode of action of agonists and antagonists. Birkhäuser Verlag Basel,, 2000 Key words. Nuclear receptor nationallicence ligand-dependent regulation of transcription nationallicence chromatin remodeling nationallicence DNA-binding domain nationallicence ligand-binding domain nationallicence ligand-induced conformational change nationallicence agonist nationallicence antagonist nationallicence Renaud J. P. Laborataire de Biologie et Génomique Structurale, CNRS UPR 9004, Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P. 163, F-67404 Illkirch (France), Fax +33 3 88 65 32 76, e-mail: moras@igbmc.u-strasbg.fr, FR aut Moras* D. Laborataire de Biologie et Génomique Structurale, CNRS UPR 9004, Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P. 163, F-67404 Illkirch (France), Fax +33 3 88 65 32 76, e-mail: moras@igbmc.u-strasbg.fr, FR aut https://doi.org/10.1007/PL00000656 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000656 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Renaud J. P. Laborataire de Biologie et Génomique Structurale, CNRS UPR 9004, Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P. 163, F-67404 Illkirch (France), Fax +33 3 88 65 32 76, e-mail: moras@igbmc.u-strasbg.fr, FR aut NATIONALLICENCE 700 1- Moras* D. Laborataire de Biologie et Génomique Structurale, CNRS UPR 9004, Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P. 163, F-67404 Illkirch (France), Fax +33 3 88 65 32 76, e-mail: moras@igbmc.u-strasbg.fr, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer