caa a22 4500 475845536 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00000651 doi (NATIONALLICENCE)springer-10.1007/PL00000651 Hedgehog signaling in vertebrate and invertebrate limb patterning [Elektronische Daten] [J. Capdevila*, R. L. Johnson] Abstract.: Invertebrate and vertebrate limbs have very different anatomies and modes of development. Despite these differences, recent studies demonstrate that a significant overlap exists in the signals used to pattern invertebrate and vertebrate limbs. One of these signaling molecules is Hedgehog, a secreted protein that functions to coordinate growth and proliferation along the anterior-posterior axis of developing limbs. Recent studies indicate that the mechanism of action, regulation and function of Hedgehog signaling in Drosophila and vertebrate limb development are often quite similar, yet at other times are distinct. Here we highlight the similarities and differences between the use of Hedgehog signaling in these two systems. Birkhäuser Verlag Basel,, 2000 Key words.Drosophila nationallicence hedgehog nationallicence limb development nationallicence mouse nationallicence chick nationallicence Capdevila* J. Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, (California 92037-1099, USA), Fax +1 858 453 2573, e-mail: jcapdevila@ems.salk.edu, US aut Johnson R. L. Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas(Texas, USA), US aut https://doi.org/10.1007/PL00000651 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000651 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Capdevila* J. Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, (California 92037-1099, USA), Fax +1 858 453 2573, e-mail: jcapdevila@ems.salk.edu, US aut NATIONALLICENCE 700 1- Johnson R. L. Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas(Texas, USA), US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer