caa a22 4500 475845544 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00000650 doi (NATIONALLICENCE)springer-10.1007/PL00000650 Sonic hedgehog signaling pathway in vertebrate epithelial appendage morphogenesis: perspectives in development and evolution [Elektronische Daten] [C.-M. Chuong*, N. Patel, J. Lin, H.-S. Jung, R. B. Widelitz] Abstract.: Vertebrate epithelial appendages are elaborate topological transformations of flat epithelia into complex organs that either protrude out of external (integument) and internal (oral cavity, gut) epithelia, or invaginate into the surrounding mesenchyme. Although they have specific structures and diverse functions, most epithelial appendages share similar developmental stages, including induction, morphogenesis, differentiation and cycling. The roles of the SHH pathway are analyzed in exemplary organs including feather, hair, tooth, tongue papilla, lung and foregut. SHH is not essential for induction and differentiation, but is involved heavily in morphogenetic processes including cell proliferation (size regulation), branching morphogenesis, mesenchymal condensation, fate determination (segmentation), polarizing activities and so on. Through differential activation of these processes by SHH in a spatiotemporal-specific fashion, organs of different shape and size are laid down. During evolution, new links of developmental pathways may occur and novel forms of epithelial appendages may emerge,upon which evolutionary selections can act. Sites of major variations have progressed from the body plan to the limb plan to the epithelial appendage plan. With its powerful morphogenetic activities, the SHH pathway would likely continue to play a major role in the evolution of novel epithelial appendages. Birkhäuser Verlag Basel,, 2000 Key words. Evolution nationallicence development nationallicence skin appendages nationallicence morphogenesis nationallicence size nationallicence Chuong* C.-M Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut Patel N. Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut Lin J. Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut Jung H.-S Institute of Biotechnology, University of Helsinki and CBRC, MGH-East, Harvard Medical School and Dept. of Oral Biology, College of Dentistry, Yonsei University, Seoul (Korea), KR aut Widelitz R. B. Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut https://doi.org/10.1007/PL00000650 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000650 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chuong* C.-M Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut NATIONALLICENCE 700 1- Patel N. Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut NATIONALLICENCE 700 1- Lin J. Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut NATIONALLICENCE 700 1- Jung H.-S Institute of Biotechnology, University of Helsinki and CBRC, MGH-East, Harvard Medical School and Dept. of Oral Biology, College of Dentistry, Yonsei University, Seoul (Korea), KR aut NATIONALLICENCE 700 1- Widelitz R. B. Department of Pathology, School of Medicine, University of Southern California, 2011 Zonal Ave, HMR 315B, Los Angeles (California 90033, USA), Fax +1 323 442 3049, e-mail: chuong@pathfinder.hsc.usc.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer