caa a22 4500 475845552 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000757 doi (NATIONALLICENCE)springer-10.1007/PL00000757 Regulation of transcription factor function by phosphorylation [Elektronische Daten] [A. J. Whitmarsh, R. J. Davis*] Abstract.: Changes in protein phosphorylation represent a mechanism that is frequently employed by cells to regulate transcription factor activity. In response to alterations in the extracellular environment, signal transduction pathways target transcription factors, transcriptional coregulators and chromatin-modifying factors, leading to their phosphorylation by protein kinases or dephosphorylation by protein phosphatases. These modifications either positively or negatively regulate transcription factor activity to facilitate a program of gene expression that results in appropriate changes in cell behavior. Protein phosphorylation and dephosphorylation can directly regulate distinct aspects of transcription factor function, including cellular localization, protein stability, protein-protein interactions and DNA binding. The phosphorylation-dependent modulation of the activities of transcriptional coregulators and chromatin-modifying factors can also control transcription factor activity. Here we review recent studies that have led to a better understanding of the mechanisms by which protein phosphorylation and dephosphorylation governs transcription factor function. Birkhäuser Verlag Basel,, 2000 Key words. Transcription factor nationallicence protein kinase nationallicence protein phosphatase nationallicence phosphorylation nationallicence signal transduction nationallicence Whitmarsh A. J. Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester (Massachusetts 01605, USA), Fax +1 508 856 3210, e-mail: roger.davis@umassmed.edu, US aut Davis* R. J. Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester (Massachusetts 01605, USA), Fax +1 508 856 3210, e-mail: roger.davis@umassmed.edu, US aut https://doi.org/10.1007/PL00000757 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000757 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Whitmarsh A. J. Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester (Massachusetts 01605, USA), Fax +1 508 856 3210, e-mail: roger.davis@umassmed.edu, US aut NATIONALLICENCE 700 1- Davis* R. J. Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester (Massachusetts 01605, USA), Fax +1 508 856 3210, e-mail: roger.davis@umassmed.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer