caa a22 4500 475845609 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000766 doi (NATIONALLICENCE)springer-10.1007/PL00000766 Signaling by reactive oxygen species in the nervous system [Elektronische Daten] [P. Maher*, D. Schubert] Abstract.: Free radicals and reactive oxygen species (ROS) are involved in a variety of different cellular processes ranging from apoptosis and necrosis to cell proliferation and carcinogenesis. Cells contain multiple sites for ROS production and a few mechanisms for their degradation. Which of these sites is activated by a given stimulus may play a role in dictating the subsequent downstream effects of the ROS generated on cellular function. Even when the ultimate outcome is similar, such as when ROS production leads to cell death, the specific cellular changes can be quite different depending on the initial stimulus and the type of cell involved. These data, along with the evidence that ROS can modify a number of intracellular signaling pathways including protein phosphatases, protein kinases and transcription factors, suggest that the majority of the effects of ROS on cells are through their actions on signaling pathways rather than via nonspecific damage of intracellular macromolecules. Birkhäuser Verlag Basel,, 2000 Key words. ROS nationallicence apoptosis nationallicence necrosis nationallicence glutathione nationallicence H2O2 nationallicence transcription factors nationallicence tyrosine phosphatases nationallicence protein kinases nationallicence Maher* P. The Scripps Research Institute, Department of Cell Biology, 10550 N. Torrey Pines Rd., La Jolla (California 92037, USA), Fax +1 858 784 7675, e-mail: pmaher@scripps.edu, US aut Schubert D. The Salk Institute for Biological Studies, Cellular Neurobiology Lab, 10010 N. Torrey Pines Rd., La Jolla (California 92037, USA), Fax +1 858 535 9062, e-mail: schubert@salk.edu, US aut https://doi.org/10.1007/PL00000766 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000766 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maher* P. The Scripps Research Institute, Department of Cell Biology, 10550 N. Torrey Pines Rd., La Jolla (California 92037, USA), Fax +1 858 784 7675, e-mail: pmaher@scripps.edu, US aut NATIONALLICENCE 700 1- Schubert D. The Salk Institute for Biological Studies, Cellular Neurobiology Lab, 10010 N. Torrey Pines Rd., La Jolla (California 92037, USA), Fax +1 858 535 9062, e-mail: schubert@salk.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer