caa a22 4500 475845617 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000765 doi (NATIONALLICENCE)springer-10.1007/PL00000765 Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores [Elektronische Daten] [J. W. Putney Jr.*, C. M. Pedrosa Ribeiro] Abstract.: This review discusses multiple ways in which the endoplasmic reticulum participates in and is influenced by signal transduction pathways. The endoplasmic reticulum provides a Ca2+ store that can be mobilized either by calcium-induced calcium release or by the diffusible messenger inositol 1,4,5-trisphosphate. Depletion of endoplasmic reticulum Ca2+ stores provides a signal that activates surface membrane Ca2+ channels, a process known as capacitative calcium entry. Depletion of endoplasmic reticulum stores can also signal long-term cellular responses such as gene expression and programmed cell death or apoptosis. In addition to serving as a source of cellular signals, the endoplasmic reticulum is also functionally and structurally modified by the Ca2+ and protein kinase C pathways. Elevated cytoplasmic Ca2+ causes a rearrangement and fragmentation of endoplasmic reticulum membranes. Protein kinase C activation reduces the storage capacity of the endoplasmic reticulum Ca2+ pool. In some cell types, protein kinase C inhibits capacitative calcium entry. Protein kinase C activation also protects the endoplasmic reticulum from the structural effects of high cytoplasmic Ca2+. The emerging view is one of a complex network of pathways through which the endoplasmic reticulum and the Ca2+ and protein kinase C signaling pathways interact at various levels regulating cellular structure and function. Birkhäuser Verlag Basel,, 2000 Key words. Calcium signaling nationallicence calcium pools nationallicence capacitative calcium entry nationallicence gene expression nationallicence apoptosis nationallicence endoplasmic reticulum structure nationallicence protein kinase C nationallicence Putney Jr.* J. W. Calcium Regulation Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences—NIH, PO Box 12233, Research Triangle Park (North Carolina 27709, USA), Fax +1 919 541 1898, e-mail: putney@niehs.nih.gov, US aut Pedrosa Ribeiro C. M. Cystic Fibrosis Pulmonary Research and Training Center, The University of North Carolina School of Medicine, Chapel Hill (North Carolina 27599, USA), US aut https://doi.org/10.1007/PL00000765 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000765 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Putney Jr.* J. W. Calcium Regulation Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences—NIH, PO Box 12233, Research Triangle Park (North Carolina 27709, USA), Fax +1 919 541 1898, e-mail: putney@niehs.nih.gov, US aut NATIONALLICENCE 700 1- Pedrosa Ribeiro C. M. Cystic Fibrosis Pulmonary Research and Training Center, The University of North Carolina School of Medicine, Chapel Hill (North Carolina 27599, USA), US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer