caa a22 4500 475845625 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000758 doi (NATIONALLICENCE)springer-10.1007/PL00000758 Regulation of gene expression by transcription factor acetylation [Elektronische Daten] [A. J. Bannister*, E. A. Miska] Abstract.: In the nucleus, DNA is tightly packaged into higher-order structures, generating an environment that is highly repressive towards DNA processes such as gene transcription. Acetylation of lysine residues within proteins has recently emerged as a major mechanism used by the cell to overcome this repression. Acetylation of non-histone proteins, including transcription factors, as well as histones, appears to be involved in this process. Like phosphorylation, acetylation is a dynamic process that can regulate protein-DNA and protein-protein interactions. Moreover, a conserved domain, the bromodomain, has been implicated in the binding of acetylated peptides, suggesting a role for acetylation in intracellular signalling. Birkhäuser Verlag Basel,, 2000 Key words. Acetyltransferase nationallicence histones nationallicence acetylation nationallicence transcription factors nationallicence gene expression nationallicence chromatin nationallicence Bannister* A. J. Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR (United Kingdom), Fax +44 1223 334089, e-mail: ab149@mole.bio.cam.ac.uk, GB aut Miska E. A. Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR (United Kingdom), Fax +44 1223 334089, e-mail: ab149@mole.bio.cam.ac.uk, GB aut https://doi.org/10.1007/PL00000758 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000758 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bannister* A. J. Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR (United Kingdom), Fax +44 1223 334089, e-mail: ab149@mole.bio.cam.ac.uk, GB aut NATIONALLICENCE 700 1- Miska E. A. Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR (United Kingdom), Fax +44 1223 334089, e-mail: ab149@mole.bio.cam.ac.uk, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer