caa a22 4500 475845641 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000756 doi (NATIONALLICENCE)springer-10.1007/PL00000756 Reece R. J. The University of Manchester, School of Biological Sciences, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT (United Kingdom), Fax +44 161 275 5317, e-mail: Richard.Reece@man.ac.uk, GB aut Molecular basis of nutrient-controlled gene expression in Saccharomyces cerevisiae [Elektronische Daten] [R. J. Reece] Abstract.: The ability of a unicellular organism to alter patterns of gene expression in response to nutrient availability is essential to its survival in a changing environment. How is the cell able to identify individual metabolites amongst a myriad of other similar molecules, and convert the information of its presence into a concerted change in the transcription of the genes required for the response to that metabolite? There is increasing evidence that the activity of transcription factors can be influenced directly by interaction with metabolites. A variety of mechanisms have been identified by which this type of gene regulation by small molecules can occur. Birkhäuser Verlag Basel,, 2000 Key words. Genetic switches nationallicence transcriptional control nationallicence metabolic regulation nationallicence Leu3p nationallicence Gal4p nationallicence Ppr1p nationallicence https://doi.org/10.1007/PL00000756 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000756 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Reece R. J. The University of Manchester, School of Biological Sciences, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT (United Kingdom), Fax +44 161 275 5317, e-mail: Richard.Reece@man.ac.uk, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer