caa a22 4500 47584565X CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000761 doi (NATIONALLICENCE)springer-10.1007/PL00000761 Peripheral B cell survival [Elektronische Daten] [F. Agenès, M. M. Rosado, A. A. Freitas*] Abstract.: Recent findings suggest that lymphocyte survival is a continuous active process and support the role of B cell receptor engagement in B cell survival. In this context the conflict of survival interests between the diverse B cells gives rise to a pattern of interactions which mimics the behavior of complex ecological systems. In response to competition lymphocytes modify their survival requirements and diverge to occupy different immunological niches through differentiation. Thus naive and memory-activated B cell populations show independent homeostatic regulation. We discuss how niche differentiation allows the coexistence of different cell types and guarantees both repertoire diversity and efficient immune responses. Birkhäuser Verlag Basel,, 2000 Key words. B lymphocytes nationallicence survival nationallicence competition nationallicence homeostasis nationallicence B cell receptor nationallicence Agenès F. Basel Institute for Immunology, Grenzacherstrasse 487, 4005 Basel (Switzerland), CH aut Rosado M. M. Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris (France) e-mail: afreitas@pasteur.fr, Web site: http://www.pasteur.fr/recherche/unites/BPL/Welcome.html, FR aut Freitas* A. A. Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris (France) e-mail: afreitas@pasteur.fr, Web site: http://www.pasteur.fr/recherche/unites/BPL/Welcome.html, FR aut https://doi.org/10.1007/PL00000761 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000761 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agenès F. Basel Institute for Immunology, Grenzacherstrasse 487, 4005 Basel (Switzerland), CH aut NATIONALLICENCE 700 1- Rosado M. M. Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris (France) e-mail: afreitas@pasteur.fr, Web site: http://www.pasteur.fr/recherche/unites/BPL/Welcome.html, FR aut NATIONALLICENCE 700 1- Freitas* A. A. Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris (France) e-mail: afreitas@pasteur.fr, Web site: http://www.pasteur.fr/recherche/unites/BPL/Welcome.html, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer