caa a22 4500 475845668 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000759 doi (NATIONALLICENCE)springer-10.1007/PL00000759 Nucleocytoplasmic shuttling of transcription factors [Elektronische Daten] [P. Cartwright, K. Helin*] Abstract.: To elicit the transcriptional response following intra- or extracellular stimuli, the signals need to be transmitted to their site of action within the nucleus. The nucleocytoplasmic shuttling of transcription factors is a mechanism mediating this process. The activation and inactivation of the transcriptional response is essential for cells to progress through the cell cycle in a normal manner. The involvement of cytoplasmic and nuclear accessory molecules, and the general nuclear membrane transport components, are essential for this process. Although nuclear import and export for different transcription factor families are regulated by similar mechanisms, there are several differences that allow for the specific activation of each transcription factor. This review discusses the general import and export pathways found to be common amongst many different transcription factors, and highlights a select group of transcription factors that demonstrate the diversity displayed in their mode of activation and inactivation. Birkhäuser Verlag Basel,, 2000 Key words. Transcription factors nationallicence nuclear shuttling nationallicence export nationallicence import nationallicence cell cycle nationallicence Cartwright P. Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan (Italy), Fax +39 02 57489860, e-mail: khelin@ieo.it, IT aut Helin* K. Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan (Italy), Fax +39 02 57489860, e-mail: khelin@ieo.it, IT aut https://doi.org/10.1007/PL00000759 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000759 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cartwright P. Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan (Italy), Fax +39 02 57489860, e-mail: khelin@ieo.it, IT aut NATIONALLICENCE 700 1- Helin* K. Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan (Italy), Fax +39 02 57489860, e-mail: khelin@ieo.it, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer