caa a22 4500 475845684 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00000760 doi (NATIONALLICENCE)springer-10.1007/PL00000760 Regulation of transcription factors by protein degradation [Elektronische Daten] [J. M. P. Desterro, M. S. Rodriguez, R. T. Hay*] Abstract.: The level of transcription factors is tightly controlled by their rates of synthesis and degradation. Many critical factors are maintained at an appropriate level by targeted addition of ubiquitin and degradation via the proteasome. Whereas ubiquitination targets modified proteins for degradation, modification of substrates by the family of ubiquitin-like proteins does not target the proteins for degradation but can alter the stability and other properties of the modified proteins. Here we discuss the elaborate mechanisms that have evolved to allow specific recognition of substrates targeted for modification. Specific examples are discussed to illustrate the different mechanisms involved and the importance of regulated degradation in diseases such as cancer. Birkhäuser Verlag Basel,, 2000 Key words. Transcription nationallicence protein degradation nationallicence ubiquitin nationallicence SUMO-1 nationallicence Desterro J. M. P. School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk, GB aut Rodriguez M. S. School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk, GB aut Hay* R. T. School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk, GB aut https://doi.org/10.1007/PL00000760 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000760 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Desterro J. M. P. School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk, GB aut NATIONALLICENCE 700 1- Rodriguez M. S. School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk, GB aut NATIONALLICENCE 700 1- Hay* R. T. School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer