caa a22 4500 475845730 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00000705 doi (NATIONALLICENCE)springer-10.1007/PL00000705 Dysfunctional insulin secretion in type 2 diabetes: role of metabolic abnormalities [Elektronische Daten] [V. Grill*, A. Björklund] Abstract.: Insulin secretion is finely tuned to the requirements of tissues by tight coupling to prevailing blood glucose levels. The normal regulation of insulin secretion is coupled to glucose metabolism in the pancreatic B cell, a major but not exclusive signal for secretion being closure of K+ATP (adenosine triphosphate)-dependent channels in the cell membrane through an increase in cytosolic ATP/adenosine diphosphate. Insulin secretion in type 2 diabetes is abnormal in several respects due to genetic causes but also due to the metabolic environment of the pancreatic B cells. This environment may be particularly important for the deterioration of insulin secretion which occurs with increasing duration of diabetes. Factors in the environment with potential importance include overstimulation, a negative effect of hyperglycemia per se (‘glucotoxicity') as well as adverse effects of elevated fatty acids (‘lipotoxicity'). Elucidating the mechanisms behind these factors as well as their clinical importance will pave the way for treatment which could preserve B-cell function in type 2 diabetic patients. Birkhäuser Verlag Basel,, 2000 Key words. Insulin secretion nationallicence type 2 diabetes nationallicence hyperglycemia nationallicence fatty acids nationallicence islets of Langerhans nationallicence Grill* V. Department of Internal Medicine, Section Endocrinology, University Hospital of Trondheim, N-7006 Trondheim (Norway), Fax +47 73 86 75 46, e-mail: valdemar.grill@medisin.ntnu.no, NO aut Björklund A. Department of Molecular Medicine, Karolinska Institute, SE-17176 Stockholm, (Sweden), SE aut https://doi.org/10.1007/PL00000705 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000705 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grill* V. Department of Internal Medicine, Section Endocrinology, University Hospital of Trondheim, N-7006 Trondheim (Norway), Fax +47 73 86 75 46, e-mail: valdemar.grill@medisin.ntnu.no, NO aut NATIONALLICENCE 700 1- Björklund A. Department of Molecular Medicine, Karolinska Institute, SE-17176 Stockholm, (Sweden), SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer