caa a22 4500 475845749 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00000709 doi (NATIONALLICENCE)springer-10.1007/PL00000709 Molecular modeling of mammalian cytochrome P450s [Elektronische Daten] [R. Dai, M. R. Pincus, F. K. Friedman*] Abstract.: The cytochrome P450s are a superfamily of hemoprotein enzymes responsible for the metabolism of a wide variety of xenobiotic and endogenous compounds. The individual P450s exhibit unique substrate specificity and stereoselectivity profiles which reflect corresponding differences in primary sequence and tertiary structure. In the absence of an experimental structure, models for mammalian P450s have been generated by their homology with bacterial P450s of known structure. The rather low sequence identity between target and template proteins renders P450 modeling a challenging task. However, the substrate recognition properties of several P450s are consistent with recently developed working models. This review summarizes the major concepts and current approaches of molecular modeling of P450s. Birkhäuser Verlag Basel,, 2000 Key words. Cytochrome P450 nationallicence molecular modeling nationallicence protein structure nationallicence drug metabolism nationallicence Dai R. Laboratory of Molecular Carcinogenesis, National Cancer Institute, Building 37 Room 3E-24, Bethesda (Maryland 20892, USA), Fax +1 301 496 8419, e-mail: fkfried@helix.nih.gov, US aut Pincus M. R. Department of Pathology and Laboratory Medicine, Veterans Administration Medical Center, Brooklyn (New York 11209, USA) and Department of Pathology, SUNY Health Science Center, 450 Clarkson Avenue, Brooklyn (New York 11239, USA), US aut Friedman* F. K. Laboratory of Molecular Carcinogenesis, National Cancer Institute, Building 37 Room 3E-24, Bethesda (Maryland 20892, USA), Fax +1 301 496 8419, e-mail: fkfried@helix.nih.gov, US aut https://doi.org/10.1007/PL00000709 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000709 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dai R. Laboratory of Molecular Carcinogenesis, National Cancer Institute, Building 37 Room 3E-24, Bethesda (Maryland 20892, USA), Fax +1 301 496 8419, e-mail: fkfried@helix.nih.gov, US aut NATIONALLICENCE 700 1- Pincus M. R. Department of Pathology and Laboratory Medicine, Veterans Administration Medical Center, Brooklyn (New York 11209, USA) and Department of Pathology, SUNY Health Science Center, 450 Clarkson Avenue, Brooklyn (New York 11239, USA), US aut NATIONALLICENCE 700 1- Friedman* F. K. Laboratory of Molecular Carcinogenesis, National Cancer Institute, Building 37 Room 3E-24, Bethesda (Maryland 20892, USA), Fax +1 301 496 8419, e-mail: fkfried@helix.nih.gov, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer