caa a22 4500 475845773 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00000711 doi (NATIONALLICENCE)springer-10.1007/PL00000711 Immunomodulation by recombinant human interleukin-8 and its signal transduction pathways in invertebrate hemocytes [Elektronische Daten] [E. Ottaviani*, A. Franchini, D. Malagoli, S. Genedani] Abstract.: We report the presence of interleukin (IL)-8-immunoreactive molecules in hemocytes from the mollusc Mytilus galloprovincialis. Functional studies demonstrate that recombinant human (rh)IL-8 provokes conformational changes, induces chemotaxis, and increases bacterial phagocytic activity in hemocytes. rhIL-8 induces cell shape changes via protein kinase A and C pathways. These morphological changes are followed by reorganization of the actin microfilaments. The findings suggest that, as previously reported for other cytokines, IL-8 is well conserved and deeply involved in immune functions from invertebrates to mammals. Birkhäuser Verlag Basel,, 2000 Key words. Mollusc nationallicence hemocyte nationallicence immune response nationallicence signalling pathway nationallicence interleukin-8 nationallicence Ottaviani* E. Department of Animal Biology, via Berengario, 14, University of Modena and Reggio Emilia, I-41100 Modena (Italy), Fax +39 59 226769, e-mail: ottaviani.enzo@unimo.it, IT aut Franchini A. Department of Animal Biology, via Berengario, 14, University of Modena and Reggio Emilia, I-41100 Modena (Italy), Fax +39 59 226769, e-mail: ottaviani.enzo@unimo.it, IT aut Malagoli D. Department of Animal Biology, via Berengario, 14, University of Modena and Reggio Emilia, I-41100 Modena (Italy), Fax +39 59 226769, e-mail: ottaviani.enzo@unimo.it, IT aut Genedani S. Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, I-41100 Modena (Italy), IT aut https://doi.org/10.1007/PL00000711 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000711 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ottaviani* E. Department of Animal Biology, via Berengario, 14, University of Modena and Reggio Emilia, I-41100 Modena (Italy), Fax +39 59 226769, e-mail: ottaviani.enzo@unimo.it, IT aut NATIONALLICENCE 700 1- Franchini A. Department of Animal Biology, via Berengario, 14, University of Modena and Reggio Emilia, I-41100 Modena (Italy), Fax +39 59 226769, e-mail: ottaviani.enzo@unimo.it, IT aut NATIONALLICENCE 700 1- Malagoli D. Department of Animal Biology, via Berengario, 14, University of Modena and Reggio Emilia, I-41100 Modena (Italy), Fax +39 59 226769, e-mail: ottaviani.enzo@unimo.it, IT aut NATIONALLICENCE 700 1- Genedani S. Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, I-41100 Modena (Italy), IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer