caa a22 4500 47584579X CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00000700 doi (NATIONALLICENCE)springer-10.1007/PL00000700 Nuclear inositides: inconsistent consistencies [Elektronische Daten] [N. Divecha*, J. H. Clarke, M. Roefs, J. R. Halstead, C. D'Santos] Abstract.: It is now clear that phosphoinositides, which play a major role in the regulation of a variety of cellular processes in the cytoplasm, are found within the nucleus. Their role in this subcellular compartment is still contentious; however, data has suggested that nuclear inositides generate substrates, such as PtdIns(4,5)P2, utilised by a number of nuclear signalling pathways: for example, nuclear phospholipase C and the PtdIns 3-kinase cascade. There is also evidence that PtdIns(4,5)P2 may play a role in the localisation and regulation of a number of nuclear proteins such as the BAF complex, which is involved in the regulation of chromatin structure. Although the presence of nuclear inositides has been demonstrated in a number of different cell types, suggesting that it is ubiquitous, there are many inconsistencies within the literature concerning the locations and isotypes of enzymes that are involved in their regulation and in the potential second messengers which are generated by them. This review aims to highlight some of these inconsistencies in order to focus on areas that need further characterisation. Birkhäuser Verlag Basel,, 2000 Key words. Diacylglycerol nationallicence phospholipase C nationallicence phospholipase D nationallicence phosphoinositides nationallicence nucleus nationallicence signal transduction nationallicence Divecha* N. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut Clarke J. H. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut Roefs M. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut Halstead J. R. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut D'Santos C. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut https://doi.org/10.1007/PL00000700 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000700 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Divecha* N. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut NATIONALLICENCE 700 1- Clarke J. H. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut NATIONALLICENCE 700 1- Roefs M. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut NATIONALLICENCE 700 1- Halstead J. R. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut NATIONALLICENCE 700 1- D'Santos C. The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam (The Netherlands), e-mail: ndivecha@nki.nl, AL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer