caa a22 4500 475845803 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00000699 doi (NATIONALLICENCE)springer-10.1007/PL00000699 Nuclear calcium signalling [Elektronische Daten] [M. D. Bootman*, D. Thomas, S. C. Tovey, M. J. Berridge, P. Lipp] Abstract.: The topic of nuclear Ca2+ signalling is beset by discrepant observations of substantial nuclear/cytoplasmic gradients. The reasons why some labs have recorded such gradients, whilst other workers see equilibration of Ca2+ cyt and Ca2+ nuc using the same cells and techniques, is unexplained. Furthermore, how such gradients could arise across the NE that possesses many highly-conductive NPCs is a mystery. Although nuclei may have the capacity to be autonomous signalling entities, with functional Ca2+ release channels and an inositide cycle, the balance of evidence suggests that Ca2+ release on the inner NE does not occur during physiological stimulation. Our work suggests that elementary Ca2+ release events originating in the cytoplasm can give rise to Ca2+ nuc signals without causing elevation of the bulk cytoplasm. Clearly, the many Ca2+ signalling mechanisms that may impinge on Ca2+ nuc will remain a topic of controversy and debate for some time. Birkhäuser Verlag Basel,, 2000 Bootman* M. D. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut Thomas D. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut Tovey S. C. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut Berridge M. J. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut Lipp P. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut https://doi.org/10.1007/PL00000699 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000699 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bootman* M. D. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut NATIONALLICENCE 700 1- Thomas D. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut NATIONALLICENCE 700 1- Tovey S. C. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut NATIONALLICENCE 700 1- Berridge M. J. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut NATIONALLICENCE 700 1- Lipp P. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT (United Kingdom), GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer