caa a22 4500 475845811 CHVBK 20180406123913.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00000701 doi (NATIONALLICENCE)springer-10.1007/PL00000701 Finkbeiner* Steven Division of Neuroscience, Department of Neurology, Children's Hospital, Harvard Medical School, 320 Longwood Ave., Enders 330, Boston (Massachusetts 02115, USA), Fax +1617 730 0630, e-mail: finkbeiner_s@hub.tch.harvard.edu, US aut Calcium regulation of the brain-derived neurotrophic factor gene [Elektronische Daten] [Steven Finkbeiner*] Abstract.: Results from several laboratories have suggested that peptide factors known as neurotrophins may play roles coupling changes in synaptic activity to lasting changes in synaptic function. Consistent with this idea, increases in synaptic activity and intracellular calcium induce the expression of the gene that encodes the neurotrophin, brain-derived neurotrophic factor. Recently, a pathway has been elucidated in neurons by which the influx of extracellular calcium evokes brain-derived neurotrophic factor transcription (BDNF). Calcium activates BDNF transcription through two adjacent calcium response elements within one of the promoters of the BDNF gene. One of the two elements binds to the cyclic adenosine monophosphate (AMP) response element binding protein (CREB) transcription factor, and interfering with CREB or related family members inhibits calcium-dependent BDNF transcription. This review focuses on the mechanisms by which calcium influx regulates brain-derived neurotrophic factor expression and the implications that these results have for potential roles of neurotrophins in synaptic function. Birkhäuser Verlag Basel,, 2000 Key words. Neurotrophins nationallicence plasticity nationallicence gene expression nationallicence synapse nationallicence CREB nationallicence calcium nationallicence https://doi.org/10.1007/PL00000701 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000701 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Finkbeiner* Steven Division of Neuroscience, Department of Neurology, Children's Hospital, Harvard Medical School, 320 Longwood Ave., Enders 330, Boston (Massachusetts 02115, USA), Fax +1617 730 0630, e-mail: finkbeiner_s@hub.tch.harvard.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer