caa a22 4500 475845994 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00000624 doi (NATIONALLICENCE)springer-10.1007/PL00000624 COUP-TF orphan nuclear receptors in development and differentiation [Elektronische Daten] [F. A. Pereira, M. J. Tsai, S. Y. Tsai*] Abstract.: Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. They have been shown to negatively regulate the activation function of vitamin D, thyroid hormone, retinoic acid, the retinoid X and the peroxisome proliferator-activated receptors. COUP-TF genes have been cloned from many species and their sequences are exceptionally conserved through evolution. This suggests a critical role for the COUP-TFs in these organisms. Indeed, the Drosophila COUP-TF, seven-up and mouse COUP-TFII are essential for development and differentiation during embryogenesis. Our current understanding of COUP-TF function suggests that they serve vital physiological roles during development despite extensive overlaps of expression. This defines the COUP-TFs as important factors in regulation of development and differentiation in multiple organisms. Birkhäuser Verlag Basel,, 2000 Key words. Orphan nuclear receptors nationallicence COUP-TF nationallicence embryogenesis nationallicence Pereira F. A. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, (USA). Fax +713 798 8227, e-mail:stsai@bcm.tmc.edu, US aut Tsai M. J. Department of Medicine Baylor College of Medicine, Houston (Texas 77030, USA), US aut Tsai* S. Y. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, (USA). Fax +713 798 8227, e-mail:stsai@bcm.tmc.edu, US aut https://doi.org/10.1007/PL00000624 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000624 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pereira F. A. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, (USA). Fax +713 798 8227, e-mail:stsai@bcm.tmc.edu, US aut NATIONALLICENCE 700 1- Tsai M. J. Department of Medicine Baylor College of Medicine, Houston (Texas 77030, USA), US aut NATIONALLICENCE 700 1- Tsai* S. Y. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, (USA). Fax +713 798 8227, e-mail:stsai@bcm.tmc.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer