caa a22 4500 47584601X CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000724 doi (NATIONALLICENCE)springer-10.1007/PL00000724 Kirk K. L. Gregory Fleming James Cystic Fibrosis Research Center, UAB Dept of Physiology and Biophysics, MCLM 738, 1918 University Blvd., 1530 3rd Ave S., Birmingham (Alabama 35294-0005, USA), Fax +1 205 934 1445, e-mail: Kirk@physiology.uab.edu, US aut New paradigms of CFTR chloride channel regulation [Elektronische Daten] [K. L. Kirk] Abstract.: The Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel controls salt and water transport across epithelial tissues. Alterations in the activity of this ion channel lead to two major human diseases: cystic fibrosis (low CFTR activity) and secretory diarrhea (excessive CFTR activity). The goal of this article is to review recent developments in our understanding of two aspects of CFTR biology: (i) interactions between CFTR domains (intramolecular interactions) that control the gating of this epithelial chloride channel and (ii) interactions between CFTR and other proteins (intermolecular interactions) that couple the activity of this ion channel to additional cellular processes in epithelial cells (e.g. membrane traffic). Clarifying the nature of these interactions may lead to the development of novel strategies for treating diseases that involve the CFTR chloride channel. Birkhäuser Verlag Basel,, 2000 Key words. Cystic fibrosis nationallicence ion channels nationallicence membrane traffic nationallicence syntaxins nationallicence PDZ domains nationallicence epithelial cells nationallicence ABC transporters nationallicence cystic fibrosis transmembrane nationallicence conductance regulator nationallicence https://doi.org/10.1007/PL00000724 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000724 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kirk K. L. Gregory Fleming James Cystic Fibrosis Research Center, UAB Dept of Physiology and Biophysics, MCLM 738, 1918 University Blvd., 1530 3rd Ave S., Birmingham (Alabama 35294-0005, USA), Fax +1 205 934 1445, e-mail: Kirk@physiology.uab.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer