caa a22 4500 475846052 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000718 doi (NATIONALLICENCE)springer-10.1007/PL00000718 Molecular mimicry and the role of B lymphocytes in the processing of autoantigens [Elektronische Daten] [B. Liang, M. J. Mamula*] Abstract.: The immune system has evolved several mechanisms that provide lymphocytes with the intelligence to ignore self proteins while attacking foreign pathogenic agents. Notably, B and T lymphocytes that encounter self antigen at either the inappropriate levels or affinity are usually instructed to perish or become anergized. However, the presence of autoimmune disease suggests that the induction of self tolerance is not foolproof. In fact, autoreactive cells are now found to be normal inhabitants of the B and T lymphocyte repertoire. This review examines how foreign peptides which resemble self proteins can elicit autoimmunity that is amplified to many sites on a target autoantigen. In particular, B lymphocytes initiated by foreign molecular mimics can process and present self peptides in the shaping of autoimmune T cell responses. Birkhäuser Verlag Basel,, 2000 Key words. Molecular mimicry nationallicence autoimmunity nationallicence tolerance nationallicence autoantigen nationallicence immune tolerance nationallicence epitope spreading nationallicence Liang B. Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven (Connecticut 06520, USA), Fax +1 203 785 7053, e-mail: mark.mamula@yale.edu, US aut Mamula* M. J. Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven (Connecticut 06520, USA), Fax +1 203 785 7053, e-mail: mark.mamula@yale.edu, US aut https://doi.org/10.1007/PL00000718 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000718 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liang B. Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven (Connecticut 06520, USA), Fax +1 203 785 7053, e-mail: mark.mamula@yale.edu, US aut NATIONALLICENCE 700 1- Mamula* M. J. Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven (Connecticut 06520, USA), Fax +1 203 785 7053, e-mail: mark.mamula@yale.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer