caa a22 4500 475846060 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000721 doi (NATIONALLICENCE)springer-10.1007/PL00000721 Guilford P. Cancer Genetics Laboratory, Biochemistry Department, University of Otago, P.O. Box 56, Dunedin, (New Zealand), Fax +64 3 4797738, e-mail: parry.guilford@otago.ac.nz, NZ aut The inherited susceptibility to cancer [Elektronische Daten] [P. Guilford] Abstract.: The study of inherited cancer syndromes has led to the identification of over 25 genes directly involved in tumorigenesis. These genes have functions as diverse as signal transduction, cell cycle control, cell-to-cell adhesion, control of apoptosis, DNA repair and the maintenance of genome stability. Most cancer syndromes have a dominant pattern of inheritance, due to germline loss-of-function mutation of a tumour suppressor gene. All the recessively inherited genes have been implicated in the maintenance of genome stability. This review summarises our current understanding of the functions of the major cancer susceptibility genes. Birkhäuser Verlag Basel,, 2000 Key words. Cancer nationallicence familial nationallicence inherited nationallicence predisposition nationallicence susceptibility nationallicence gene nationallicence https://doi.org/10.1007/PL00000721 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000721 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Guilford P. Cancer Genetics Laboratory, Biochemistry Department, University of Otago, P.O. Box 56, Dunedin, (New Zealand), Fax +64 3 4797738, e-mail: parry.guilford@otago.ac.nz, NZ aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer