caa a22 4500 475846087 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000723 doi (NATIONALLICENCE)springer-10.1007/PL00000723 Nitric oxide can inhibit apoptosis or switch it into necrosis [Elektronische Daten] [G. Melino*, M. V. Catani, M. Corazzari, P. Guerrieri, F. Bernassola] Abstract.: Nitric oxide (NO) and its related molecules are important messengers that play central roles in pathophysiology. Redox modulation of thiol groups on protein cysteine residues by S-nitrosylation can modulate protein function. NO has emerged as a potent regulator of apoptosis in many cell types, either preventing cell death or driving an apoptotic response into a necrotic one. NO protects neuroblastoma cells from retinoid- and cisplatin-induced apoptosis, without significantly increasing necrotic cell damage. Nitrosylation of thiol groups of several critical factors may be important for cell survival. Indeed, S-nitrosylation of the active-site cysteine residue of apoptotic molecules, such as caspases and tissue transglutaminase, results in the inhibition of their catalytic activities and has important implications for the regulation of apoptosis by NO. On the other hand, NO is able to shift the anti-CD95- and ceramide-triggered apoptotic response of Jurkat T cells into necrotic cell death. In these apoptotic models, NO is therefore unable to solely inhibit cell death, indicating that it may act below the point of no return elicited by CD95-ligation and ceramide stimulation. Birkhäuser Verlag Basel,, 2000 Key words. Nitric oxide nationallicence S-nitrosylation nationallicence apoptosis nationallicence Melino* G. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut Catani M. V. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut Corazzari M. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut Guerrieri P. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut Bernassola F. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut https://doi.org/10.1007/PL00000723 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000723 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Melino* G. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut NATIONALLICENCE 700 1- Catani M. V. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut NATIONALLICENCE 700 1- Corazzari M. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut NATIONALLICENCE 700 1- Guerrieri P. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut NATIONALLICENCE 700 1- Bernassola F. IDI-IRCCS, Biochemistry Lab, c/o Department of Experimental Medicine, D26/F153, University of Rome Tor Vergata, Via Tor Vergata 135, I-00133 Rome (Italy), Fax +39 6 20427290, e-mail: gerry.melino@uniroma2.it, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer