caa a22 4500 475846109 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000719 doi (NATIONALLICENCE)springer-10.1007/PL00000719 Epitope mimics and determinant spreading: pathways to autoimmunity [Elektronische Daten] [A. D. Farris, C. L. Keech, T. P. Gordon, J. McCluskey*] Abstract.: Infectious microorganisms have evolved molecules which mimic the host in order to aid in their undetected propagation. In response, mammalian hosts have evolved a highly diverse immune repertoire designed to eradicate rapidly changing pathogens. The generation of diversity in the immune repertoire results in potentially damaging self cross-reactivities which require multiple regulatory controls to keep autoreactive lymphocytes in check. Here, we review how molecular mimicry at the T cell level might be important in the development of systemic autoimmunity. Birkhäuser Verlag Basel,, 2000 Key words. Determinant spreading nationallicence T cell nationallicence mimicry nationallicence autoimmunity nationallicence tolerance nationallicence Farris A. D. Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3052 (Australia), Fax +613 9347 1540, e-mail: j.mccluskey@microbiology.unimelb.edu.au, AU aut Keech C. L. Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3052 (Australia), Fax +613 9347 1540, e-mail: j.mccluskey@microbiology.unimelb.edu.au, AU aut Gordon T. P. Department of Immunology, Arthritis and Allergy, Flinders Medical Centre, Bedford Park 5042, South Australia (Australia), AU aut McCluskey* J. Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3052 (Australia), Fax +613 9347 1540, e-mail: j.mccluskey@microbiology.unimelb.edu.au, AU aut https://doi.org/10.1007/PL00000719 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000719 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Farris A. D. Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3052 (Australia), Fax +613 9347 1540, e-mail: j.mccluskey@microbiology.unimelb.edu.au, AU aut NATIONALLICENCE 700 1- Keech C. L. Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3052 (Australia), Fax +613 9347 1540, e-mail: j.mccluskey@microbiology.unimelb.edu.au, AU aut NATIONALLICENCE 700 1- Gordon T. P. Department of Immunology, Arthritis and Allergy, Flinders Medical Centre, Bedford Park 5042, South Australia (Australia), AU aut NATIONALLICENCE 700 1- McCluskey* J. Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3052 (Australia), Fax +613 9347 1540, e-mail: j.mccluskey@microbiology.unimelb.edu.au, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer