caa a22 4500 475846133 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000722 doi (NATIONALLICENCE)springer-10.1007/PL00000722 Ras-related and MAPK signalling in neuronal plasticity and memory formation [Elektronische Daten] [C. Mazzucchelli, R. Brambilla*] Abstract.: Ras-related guanosine triphosphatases (GTPases) couple receptor activity to a number of intracellular signalling events culminating in the control of cell morphology and gene transcription. In culture cells, the best-understood Ras-dependent signalling pathway involves the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK) cascade. A growing body of evidence has recently been accumulating to suggest a crucial role of Ras and MAPK signalling in neuronal functions connected to synaptic plasticity. In the present review article we discuss the experimental basis supporting the notion that the Ras/MAPK pathway interacts with other synaptic mechanisms to regulate invertebrate and vertebrate behavioural responses such as those implicated in learning and memory processes. Birkhäuser Verlag Basel,, 2000 Key words. Ras/MAPK signalling nationallicence synaptic plasticity nationallicence learning and memory nationallicence hippocampus nationallicence Mazzucchelli C. San Raffaele Scientific Institute, via Olgettina 58, I-20132 Milano (Italy), Fax +39 02 2643 4767, e-mail: r.brambilla@hsr.it, IT aut Brambilla* R. San Raffaele Scientific Institute, via Olgettina 58, I-20132 Milano (Italy), Fax +39 02 2643 4767, e-mail: r.brambilla@hsr.it, IT aut https://doi.org/10.1007/PL00000722 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000722 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mazzucchelli C. San Raffaele Scientific Institute, via Olgettina 58, I-20132 Milano (Italy), Fax +39 02 2643 4767, e-mail: r.brambilla@hsr.it, IT aut NATIONALLICENCE 700 1- Brambilla* R. San Raffaele Scientific Institute, via Olgettina 58, I-20132 Milano (Italy), Fax +39 02 2643 4767, e-mail: r.brambilla@hsr.it, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer