caa a22 4500 47584615X CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000714 doi (NATIONALLICENCE)springer-10.1007/PL00000714 Yuki N. Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293 (Japan), Fax +81 282 86 5884, e-mail: yuki@dokkyomed.ac.jp, JP aut Current cases in which epitope mimicry is considered a component cause of autoimmune disease: Guillain-Barré syndrome [Elektronische Daten] [N. Yuki] Abstract.: Some patients develop Guillain-Barré syndrome (GBS) after the administration of bovine gangliosides. Patients with GBS subsequent to Campylobacter jejuni enteritis frequently have IgG antibody to GM1 ganglioside. Miller Fisher syndrome (MFS), a variant of GBS, is associated with IgG antibody to GQ1b ganglioside. Molecular mimicry between GM1 and lipopolysaccharide of C. jejuni isolated from patients with GBS, and between GQ1b and C. jejuni lipopolysaccharides from patients with MFS have been demonstrated. The molecular mimicry between infectious agents and gangliosides may function in the production of anti-ganglioside antibodies. This sugar mimicry is one possible cause of the Guillain-Barré and Miller Fisher syndromes; however, unidentified host factors may contribute to the development of these syndromes. Birkhäuser Verlag Basel,, 2000 Key words. Molecular mimicry nationallicence Guillain-Barré syndrome nationallicence Miller Fisher syndrome nationallicence Campylobacter jejuni nationallicence lipopolysaccharide nationallicence ganglioside nationallicence https://doi.org/10.1007/PL00000714 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000714 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Yuki N. Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293 (Japan), Fax +81 282 86 5884, e-mail: yuki@dokkyomed.ac.jp, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer