caa a22 4500 475846168 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/PL00000717 doi (NATIONALLICENCE)springer-10.1007/PL00000717 Lawson C. M. Division of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, 6150 Western Australia (Australia) Fax +618 9310 4144, e-mail: cassiel@numbat.murdoch.edu.au, AU aut Evidence for mimicry by viral antigens in animal models of autoimmune disease including myocarditis [Elektronische Daten] [C. M. Lawson] Abstract.: Molecular mimicry of viral antigens with self determinants has been proposed as one of the pathogenic mechanisms in autoimmune disease. Evidence of viral mimicry in animal models of autoimmunity is accumulating. Murine adenovirus, Semliki forest virus, lactate dehydrogenase-elevating virus, herpes simplex virus type-1, hepatitis B virus, encephalomyocarditis virus, Theiler's murine encephalomyelitis virus, Coxsackievirus and cytomegalovirus have been found to mimic physiologically important host proteins. However, epitope homology of a viral and self determinant is not in itself strong evidence for mimicry as a pathogenic mechanism. The mimicking determinant must also be capable of inducing disease in the absence of replicative virus. Animal models provide evaluation of the viral trigger, and development and therapy for autoimmune diseases. Identification of host proteins that can induce disease together with the knowledge of immune system dysregulation, genetic association and environmental factors may lead to improved immunotherapeutic strategies for human autoimmune diseases. Birkhäuser Verlag Basel,, 2000 Key words. Epitope nationallicence mimicry nationallicence viral proteins nationallicence autoimmunity nationallicence animal models nationallicence https://doi.org/10.1007/PL00000717 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000717 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lawson C. M. Division of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, 6150 Western Australia (Australia) Fax +618 9310 4144, e-mail: cassiel@numbat.murdoch.edu.au, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer