caa a22 4500 475846192 CHVBK 20180406123914.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s000180050035 doi (NATIONALLICENCE)springer-10.1007/s000180050035 Molecular basis of Alzheimer's disease [Elektronische Daten] [B. Drouet, M. Pinçon-Raymond, J. Chambaz*, T. Pillot] Abstract.: Despite an exponential production of data, Alzheimer's disease (AD) remains an enigma. Unresolved questions persist in the face of the heterogeneity of this neuropathology. Recent progress in understanding mechanisms for AD results from the study of amyloid precursor protein (APP) metabolism and the involvement of senile plaque-associated proteins. In addition to the amyloid cascade hypothesis, alternative schemes emerge, in which the amyloid peptide is not the primary effector of the disease. Perturbations of vesicular trafficking, the cytoskeletal network, and membrane cholesterol distribution could be central events. Furthermore, since the physiological role of APP, presenilins, and apolipoprotein E in the central nervous system are not completely understood, their involvement in AD etiology remains speculative. New actors have to be found to try to explain sporadic cases and non-elucidated familial cases. Birkhäuser Verlag Basel,, 2000 Key words. Amyloid-β peptide nationallicence presenilin nationallicence Alzheimer's disease nationallicence apolipoprotein E nationallicence cholesterol homeostasis nationallicence Drouet B. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut Pinçon-Raymond M. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut Chambaz* J. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut Pillot T. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut https://doi.org/10.1007/s000180050035 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050035 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Drouet B. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut NATIONALLICENCE 700 1- Pinçon-Raymond M. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut NATIONALLICENCE 700 1- Chambaz* J. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut NATIONALLICENCE 700 1- Pillot T. INSERM U-505, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris (France), Fax +33 1 43 25 16 15, e-mail: jean.chambaz-u505@bhdc.jussieu.fr, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer