caa a22 4500 475846222 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s000180050040 doi (NATIONALLICENCE)springer-10.1007/s000180050040 Structure and function of eukaryotic peptide transporters [Elektronische Daten] [D. Meredith*, C. A. R. Boyd] Abstract.: The cotransport of protons and peptides is now recognised as a major route by which dietary nitrogen is absorbed from the intestine, and filtered protein reabsorbed in the kidney. Recently, molecular biology has had a very substantial impact on the study of peptide transport, and here we review the molecular and functional information available within the framework of physiology. To this end we consider not only the mammalian peptide transporters and their tissue distribution and regulation but also those from other species (including Caenorhabditis elegans) which make up the proton-dependent oligopeptide transport superfamily. In addition, understanding the binding requirements for transported substrates may allow future design and targeted tissue delivery of peptide and peptidomimetic drugs. Finally, we aim to highlight some of the less well understood areas of peptide transport, in the hope that it will stimulate further research into this challenging yet exciting topic. Birkhäuser Verlag Basel,, 2000 Key words. PepT1 nationallicence PepT2 nationallicence epithelia nationallicence β-lactam antibiotics nationallicence PTR2 nationallicence oligopeptide transport nationallicence apical membrane nationallicence basolateral membrane nationallicence Meredith* D. Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD (United Kingdom) Fax 44 117 928 8274, e-mail: david.meredith@bristol.ac.uk, GB aut Boyd C. A. R. Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX (United Kingdom), Fax 44 1865 272420, e-mail: richard.boyd@human-anatomy.ox.ac.uk, GB aut https://doi.org/10.1007/s000180050040 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050040 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meredith* D. Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD (United Kingdom) Fax 44 117 928 8274, e-mail: david.meredith@bristol.ac.uk, GB aut NATIONALLICENCE 700 1- Boyd C. A. R. Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX (United Kingdom), Fax 44 1865 272420, e-mail: richard.boyd@human-anatomy.ox.ac.uk, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer