caa a22 4500 475846273 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s000180050042 doi (NATIONALLICENCE)springer-10.1007/s000180050042 Woodson S. A. T. C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore (Maryland 21218-2685, USA), Fax +1 410 516 4118, e-mail: swoodson@jhu.edu, US aut Recent insights on RNA folding mechanisms from catalytic RNA [Elektronische Daten] [S. A. Woodson] Abstract.: Methods for probing RNA structure in real time have revealed that initial folding steps are complete in less than a second. Refolding of large catalytic RNAs in vitro often results in long-lived intermediates that reach the native structure very slowly. These kinetically trapped intermediates arise from alternative secondary structures that form early in the folding process. In cells, proteins modulate the outcome of RNA folding reactions by stabilizing specific conformations or by accelerating refolding of misfolded intermediates. At the same time, competition between metastable conformations provides a means for regulating the biological activity of transcripts. Birkhäuser Verlag Basel,, 2000 Key words. RNA folding nationallicence ribozyme nationallicence energy landscape nationallicence translation attenuation nationallicence RNA structure nationallicence group I intron nationallicence RNase P nationallicence folding kinetics nationallicence transcription elongation nationallicence https://doi.org/10.1007/s000180050042 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050042 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Woodson S. A. T. C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore (Maryland 21218-2685, USA), Fax +1 410 516 4118, e-mail: swoodson@jhu.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer