caa a22 4500 475846281 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s000180050039 doi (NATIONALLICENCE)springer-10.1007/s000180050039 A possible new role for the anti-ageing peptide carnosine [Elektronische Daten] [A. R. Hipkiss*, C. Brownson] Abstract.: The naturally occurring dipeptide carnosine (β-alanyl-L-histidine) is found in surprisingly large amounts in long-lived tissues and can delay ageing in cultured human fibroblasts. Carnosine has been regarded largely as an anti-oxidant and free radical scavenger. More recently, an anti-glycating potential has been discovered whereby carnosine can react with low-molecular-weight compounds that bear carbonyl groups (aldehydes and ketones). Carbonyl groups, arising mostly from the attack of reactive oxygen species and ow-molecular-weight aldehydes and ketones, accumulate on proteins during ageing. Here we propose, with supporting evidence, that carnosine can react with protein carbonyl groups to produce protein-carbonyl-carnosine adducts (‘carnosinylated' proteins). The various possible cellular fates of the carnosinylated proteins are discussed. These proposals may help explain anti-ageing actions of carnosine and its presence in non-mitotic cells of long-lived mammals. Birkhäuser Verlag Basel,, 2000 Key words. Protein nationallicence aging nationallicence ageing nationallicence carbonyl nationallicence glycation nationallicence proteolysis nationallicence lipofuscin nationallicence advanced glycosylation end-product nationallicence Hipkiss* A. R. Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, Guy's Campus London Bridge, London, SE1 1UL (UK), Fax +44 207 848 6399, e-mail: alan.hipkiss@kcl.ac.uk, UA aut Brownson C. Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, Guy's Campus London Bridge, London, SE1 1UL (UK), Fax +44 207 848 6399, e-mail: alan.hipkiss@kcl.ac.uk, UA aut https://doi.org/10.1007/s000180050039 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050039 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hipkiss* A. R. Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, Guy's Campus London Bridge, London, SE1 1UL (UK), Fax +44 207 848 6399, e-mail: alan.hipkiss@kcl.ac.uk, UA aut NATIONALLICENCE 700 1- Brownson C. Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, Guy's Campus London Bridge, London, SE1 1UL (UK), Fax +44 207 848 6399, e-mail: alan.hipkiss@kcl.ac.uk, UA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer