caa a22 4500 475846303 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s000180050034 doi (NATIONALLICENCE)springer-10.1007/s000180050034 Ishikawa F. Tokyo Institute of Technology, Department of Life Science, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501 (Japan), e-mail: fishikaw@bio.titech.ac.jp, JP aut Aging clock: the watchmaker's masterpiece [Elektronische Daten] [F. Ishikawa] Abstract.: The phenomenon of cellular senescence has been known for almost four decades. Yet, until very recently, the molecular mechanisms that lead to senescence have been poorly understood. However, substantial progress has been made in the last few years toward identifying the pathways executing senescence. This review focuses on two major advances in this field, the telomere aging clock theory and the cell cycle regulatory mechanisms in senescent cells. These recent studies indicate that cellular senescence is a highly elaborate and active process, which presumably works as an anti-oncogenic mechanism. Birkhäuser Verlag Basel,, 2000 Key words. Senescence nationallicence telomere nationallicence telomerase nationallicence p21CIP1 nationallicence p16INK4a nationallicence p19ARF nationallicence https://doi.org/10.1007/s000180050034 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050034 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ishikawa F. Tokyo Institute of Technology, Department of Life Science, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501 (Japan), e-mail: fishikaw@bio.titech.ac.jp, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer