caa a22 4500 47584632X CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s000180050038 doi (NATIONALLICENCE)springer-10.1007/s000180050038 Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases [Elektronische Daten] [R. Nagai*, Y. Saito, Y. Ohyama, H. Aizawa, T. Suga, T. Nakamura, M. Kurabayashi, M. Kuro-o] Abstract.: The human aging process is associated with vascular endothelial dysfunction. However, humoral factors which might protect against endothelial dysfucntion during aging have not yet been identified. We recently identified the klotho gene as a possible regulator of human aging. In the present study using the klotho-deficient heterozygous mouse, we examined whether the Klotho protein is a humoral factor protecting against endothelial dysfunction. We further cloned rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress. The Klotho protein itself, or its metabolites, promotes endothelial NO production in aorta as well as arterioles, and klotho mRNA in kidney is downregulated under sustained circulatory stress. Birkhäuser Verlag Basel,, 2000 Key words.klotho nationallicence endothelial function nationallicence nitric oxide production nationallicence hypertension nationallicence renal failure nationallicence cytokine nationallicence Nagai* R. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Saito Y. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Ohyama Y. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Aizawa H. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Suga T. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Nakamura T. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Kurabayashi M. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut Kuro-o M. University of Texas Southwestern Medical Center, Dallas (Texas, USA), US aut https://doi.org/10.1007/s000180050038 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s000180050038 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nagai* R. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Saito Y. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Ohyama Y. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Aizawa H. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Suga T. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Nakamura T. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Kurabayashi M. Second Department of Internal Medicine, Gunma University School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511 (Japan), Fax +81 27 220 8150, e-mail: nagai@news.sb.gunma-u.ac.jp, JP aut NATIONALLICENCE 700 1- Kuro-o M. University of Texas Southwestern Medical Center, Dallas (Texas, USA), US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer