caa a22 4500 475846338 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/PL00000692 doi (NATIONALLICENCE)springer-10.1007/PL00000692 P58IPK, a novel cochaperone containing tetratricopeptide repeats and a J-domain with oncogenic potential [Elektronische Daten] [M. W. Melville**, M. G. Katze*, S.-L. Tan] Abstract.: Tetratricopeptide repeats (TPRs) are loosely conserved 34-amino acid sequence motifs that have been shown to function as scaffolding structures to mediate protein-protein interactions. TPRs have been identified in a number of proteins with diverse functions and cellular locations. Recent studies suggest that individual TPR motifs can confer specificity in promoting homotypic and/or heterotypic interactions, often in a mutually exclusive manner. These features are best exemplified by the P58IPK protein, an influenza virus-activated cellular inhibitor of the PKR protein kinase, whose different TPR motifs mediate interactions with distinct proteins. P58IPK, which possesses cochaperone and oncogenic properties, represents a unique class of TPR proteins containing a J-domain. Here we review recent progress on the structural and functional characterization of P58IPK, and discuss the possible mechanisms by which P58IPK modulates PKR and induces tumorigenesis in view of present knowledge of TPR proteins and molecular chaperones. Birkhäuser Verlag Basel,, 2000 Key words. Tetratricopeptide repeat nationallicence J-domain nationallicence P58IPK nationallicence PKR nationallicence protein-protein interactions nationallicence cochaperone nationallicence protein folding nationallicence tumorigenesis nationallicence Melville** M. W. Department of Microbiology, School of Medicine, University of Washington, Seattle (Washington 98195, USA), US aut Katze* M. G. Department of Microbiology, School of Medicine, Box 357242, University of Washington, 1705 Pacific St. NE, Seattle (Washington 98195, USA), Fax +1 206 685 0305; e-mail:honey@u.washington.edu, US aut Tan S.-L Department of Microbiology, School of Medicine, Box 357242, University of Washington, 1705 Pacific St. NE, Seattle (Washington 98195, USA), Fax +1 206 685 0305; e-mail:honey@u.washington.edu, US aut https://doi.org/10.1007/PL00000692 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000692 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Melville** M. W. Department of Microbiology, School of Medicine, University of Washington, Seattle (Washington 98195, USA), US aut NATIONALLICENCE 700 1- Katze* M. G. Department of Microbiology, School of Medicine, Box 357242, University of Washington, 1705 Pacific St. NE, Seattle (Washington 98195, USA), Fax +1 206 685 0305; e-mail:honey@u.washington.edu, US aut NATIONALLICENCE 700 1- Tan S.-L Department of Microbiology, School of Medicine, Box 357242, University of Washington, 1705 Pacific St. NE, Seattle (Washington 98195, USA), Fax +1 206 685 0305; e-mail:honey@u.washington.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer