caa a22 4500 475846354 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/PL00000690 doi (NATIONALLICENCE)springer-10.1007/PL00000690 Yamaguchi Y. aut Lecticans: organizers of the brain extracellular matrix [Elektronische Daten] [Y. Yamaguchi] Abstract.: Lecticans are a family of chondroitin sulfate proteoglycans, encompassing aggrecan, versican, neurocan and brevican. These proteoglycans are characterized by the presence of ahyaluronan-binding domain and a C-type lectin domain in their core proteins. Through these domains, lecticans interact with carbohydrate and protein ligands in the extracellular matrix and act as linkers of these extracellular matrix molecules. In adult brain, lecticans are thought to interact with hyaluronan and tenascin-R to form a ternary complex. We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as ‘perineuronal nets'. Birkhäuser Verlag Basel,, 2000 Key words. Proteoglycan nationallicence chondroitin sulfate nationallicence extracellular matrix nationallicence nervous system nationallicence neurite outgrowth nationallicence axon regeneration nationallicence https://doi.org/10.1007/PL00000690 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000690 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Yamaguchi Y. aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer