caa a22 4500 475846370 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/PL00000686 doi (NATIONALLICENCE)springer-10.1007/PL00000686 Soluble factors and the development of rod photoreceptors [Elektronische Daten] [E. M. Levine*, S. Fuhrmann, T. A. Reh**] Abstract.: Photoreceptors are the most abundant cell type in the vertebrate neural retina. Like the other retinal neurons and the Müller glia, they arise from a population of precursor cells that are multipotent and intrinsic to the retina. Approximately 10 years ago, several studies demonstrated that retinal precursor cells (RPCs) are competent to respond to environmental factors that promote cell type determination and differentiation. Since those studies, significant effort has been directed at identifying the molecular nature of these environmental signals and understanding the precise mechanisms they employ to drive RPCs towards the different retinal fates. In this review, we describe the recent progress toward understanding how environmental factors influence the development of vertebrate rod photoreceptors. Birkhäuser Verlag Basel,, 2000 Key words. Retina nationallicence signaling factors nationallicence retinoic acid nationallicence Hedgehog nationallicence fibroblast growth factor nationallicence epidermal growth factor nationallicence ciliary neurotrophic factor nationallicence Levine* E. M. Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US aut Fuhrmann S. Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US aut Reh** T. A. Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US aut https://doi.org/10.1007/PL00000686 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000686 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levine* E. M. Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US aut NATIONALLICENCE 700 1- Fuhrmann S. Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US aut NATIONALLICENCE 700 1- Reh** T. A. Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer